Journal: Nature Reviews. Genetics

Article Title: Human organs-on-chips for disease modelling, drug development and personalized medicine

doi: 10.1038/s41576-022-00466-9

Figure Lengend Snippet: Human disease states and clinical responses replicated in single organ chips

Article Snippet: , 3-Channel PDMS ECM gel , Epi, endo, cancer , Inflammation , Nanocarrier delivery , .

Techniques: Drug Transport Assay, Plasmid Preparation, Adjuvant, Bacteria, Virus, Infection, Gene Expression, Filtration, High Throughput Screening Assay, Mutagenesis, Isolation

Journal: Experimental Biology and Medicine

Article Title: Blood–brain barrier-on-a-chip: Microphysiological systems that capture the complexity of the blood–central nervous system interface

doi: 10.1177/1535370217694100

Figure Lengend Snippet: Summary of current BBB organ-on-chips and their key features

Article Snippet: 2012 , Yeon et al. 72 , Rectangular PDMS channel (25 μm in height) , Primary HUVEC (Sciencell) , N/A (+Astrocyte conditioned media) , ZO-1 , N/A , 4, 40, 70 kDa dextran (relative comparison) , N/A , N/A.

Techniques: Permeability, Shear, Comparison, Activity Assay

Journal: Biosensors

Article Title: Recent Progress in PDMS-Based Microfluidics Toward Integrated Organ-on-a-Chip Biosensors and Personalized Medicine

doi: 10.3390/bios15020076

Figure Lengend Snippet: The main steps of the photolithography technique for microfluidic device fabrication including cleaning the substrate wafer, depositing the photoresist on a silicon substrate, baking the wafer into the oven, aligning the photomask containing the pattern with the substrate, exposing the photoresist to UV, immersing the coated substrate in a solvent, rinsing the substrate with DI water, baking the wafer, depositing PDMS, and separating the polymer from the substrate and bonded with flat slide.

Article Snippet: The biomimetic microfluidic device was built using a matching design of PDMS channels sandwiched between two PMMA layers, as shown in a.

Techniques: Solvent, Polymer

Journal: Biosensors

Article Title: Recent Progress in PDMS-Based Microfluidics Toward Integrated Organ-on-a-Chip Biosensors and Personalized Medicine

doi: 10.3390/bios15020076

Figure Lengend Snippet: The main steps of PDMS-based microfluidic system fabrication using ( a ) the injection molding method; ( b ) the hot embossing methods.

Article Snippet: The biomimetic microfluidic device was built using a matching design of PDMS channels sandwiched between two PMMA layers, as shown in a.

Techniques: Injection

Journal: Biosensors

Article Title: Recent Progress in PDMS-Based Microfluidics Toward Integrated Organ-on-a-Chip Biosensors and Personalized Medicine

doi: 10.3390/bios15020076

Figure Lengend Snippet: The setup of the PDMS microfluidic system integrated into an optical fiber sensor containing SMF, 1310 nm laser system, and photodetector for the monitoring Saccharomyces cerevisiae cells concentration depending on the light scattering inside the microchamber . Adapted with permission from reference .

Article Snippet: The biomimetic microfluidic device was built using a matching design of PDMS channels sandwiched between two PMMA layers, as shown in a.

Techniques: Concentration Assay

Journal: Biosensors

Article Title: Recent Progress in PDMS-Based Microfluidics Toward Integrated Organ-on-a-Chip Biosensors and Personalized Medicine

doi: 10.3390/bios15020076

Figure Lengend Snippet: A schematic view of a liver-on-chip microfluidic platform ( a ) layers and ( b ) assembly, using a PMMA bioreactor with PDMS microwell inserts for glucose metabolism and mitochondrial function ; ( c ) Schematic diagram of ExoLiver integrating three electrochemical dissolved oxygen (DO) sensors; ( d ) Cross-sectional view of the system featuring the three sensors embedded within the porous membrane. ( e ) An illustration of the system assembly . Adapted with permission from references [ , ].

Article Snippet: The biomimetic microfluidic device was built using a matching design of PDMS channels sandwiched between two PMMA layers, as shown in a.

Techniques: Membrane

Journal: Biosensors

Article Title: Recent Progress in PDMS-Based Microfluidics Toward Integrated Organ-on-a-Chip Biosensors and Personalized Medicine

doi: 10.3390/bios15020076

Figure Lengend Snippet: In ( a ) Design assembly of PDMS Blood-Brain Barrier (BBB) model for drug permeability screening; ( b ) Cross section view of the system integrating TEER electrodes across a co-culture of brain microvascular endothelial cells (BMECs) and rat primary ; ( c , d ) PDMS- based device incorporating TEER sensor with 16-unit chip co-culturing primary neurovascular endothelial cells and astrocytes ; ( e ) A schematic illustration of a PDMS-based microfluidic system integrating a MEA to mimic neural network responses . Adapted with permission from references [ , , ].

Article Snippet: The biomimetic microfluidic device was built using a matching design of PDMS channels sandwiched between two PMMA layers, as shown in a.

Techniques: Permeability, Co-Culture Assay